Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism
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چکیده
منابع مشابه
PT680. Distribution and brain function of Hyaluronan Binding Protein Involved in Hyaluronan Depolymerization (HYBID, KIAA1199) in mouse central nerve system.
s | 47 of oxytocin. Moreover, the degree of neural overlap was significantly low in ASD model mice. These findings offer insight into our understanding of the neural mechanisms of empathy and the development of therapeutic treatment of ASD. PT677 c-Fos immunoreactivity in hypoactive and hyperactive Dopamine-deficient mice Taishi Takeda, Masayo Fujita, Yoko Hagino, Kazutaka Ikeda, Masashi
متن کاملKIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.
Hyaluronan (HA) has an extraordinarily high turnover in physiological tissues, and HA degradation is accelerated in inflammatory and neoplastic diseases. CD44 (a cell surface receptor) and two hyaluronidases (HYAL1 and HYAL2) are thought to be responsible for HA binding and degradation; however, the role of these molecules in HA catabolism remains controversial. Here we show that KIAA1199, a de...
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Hyaluronan (HA) has diverse functions in normal lung homeostasis and pulmonary disease. HA constitutes the major glycosaminoglycan in lung tissue, with HA degradation products, produced by hyaluronidase enzymes and reactive oxygen species, being implicated in several lung diseases, including acute lung injury, asthma, chronic obstructive pulmonary disease, and pulmonary hypertension. The differ...
متن کاملHyaluronan-binding protein in endothelial cell morphogenesis
Previous studies from several laboratories have provided evidence that interaction of hyaluronan (HA) with the surface of endothelial cells may be involved in endothelial cell behavior. We have recently characterized a mAb, mAb IVd4, that recognizes and neutralizes HA-binding protein (HABP) from a wide variety of cell types from several different species (Banerjee, S. D., and B. P. Toole. 1991....
متن کاملpH and cation-induced thermodynamic stability of human hyaluronan binding protein 1 regulates its hyaluronan affinity.
Hyaluronan-binding protein 1 (HABP1) is a trimeric protein with high negative charges distributed asymmetrically along the faces of the molecule. Recently, we have reported that HABP1 exhibits a high degree of structural flexibility, which can be perturbed by ions under in vitro conditions near physiological pH (Jha, B. K., Salunke, D. M., and Datta, K. (2003) J. Biol. Chem. 278, 27464-27472). ...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2017
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2017.01.005